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Disease Control Rate

Also sometimes called the “clinical benefit rate,” this endpoint seeks to capture the total benefit from a drug. This recognizes that an agent does not necessarily have to shrink or eliminate the cancer to have an impact. Thus, studies often report DCR alongside the objective response rate, as the sum of the patients who had a complete response (CR), partial response (PR), and stable disease (SD), giving a calculation of CR+PR+SD. At times, this can help give more information about how a drug differs from the control of a trial, but it is usually insufficient for approval.

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